Thalassemia and Hemoglobinopathy

Front

What is the amino acid substitution in patients with sickle cell anemia?

Back

valine for glutamic acid

Front

Which of the following factors contributes to the pathophysiology of sickling? increased iron concentration, hypochromia, fava beans, dehydration

Back

dehydration

Front

Which of the following shows crystals like those seen here: Hgb CC disease, Hgb DD disease, Hgb EE disease, Hgb SC disease?

Back

Hgb CC disease

Front

The crystals seen here are associated with: Hgb CC disease, Hgb SS disease, Hgb SC disease, Hgb EE disease

Back

Hgb SC disease

Front

All but one of the following may be seen in the PB smear when a sickle cell crisis has occurred: Target cells, NRBCs, Polychromasia, Moderate elliptocytes

Back

Moderate elliptocytes

Front

List two sets of lab data that can distinguish IDA from beta thalassemia trait: Serum iron and RBC, Hgb and Hct, WBC and RDW, RBC indices and Platelets

Back

Serum iron and RBC

Front

What is the majority hemoglobin in beta thalassemia major?

Back

Hgb F

Front

Which of the following alpha thalassemia is inconsistent with life? Alpha thal trait, Alpha thal minor, Hgb H, Hgb Bart's

Back

Hgb Bart's

Front

Which of the following hemoglobins contains β₄ tetramers? Hgb Bart's, Hgb Gower, Hgb H, Hgb Portland

Back

Hgb H

Front

Which of the following hemoglobins contains γ₄ tetramers? Hgb Bart's, Hgb Gower, Hgb H, Hgb Portland

Back

Hgb Bart's