Pluripotency and Nobel Prize Flashcard

Front

Who received the Nobel Prize in Physiology and Medicine in 2012 for the discovery that mature cells can be reprogrammed to become pluripotent?

Back

Dr. Shinya Yamanaka and Dr. John Gurdon

Front

What is the role of Oct4/Sox2 in pluripotency?

Back

Maintain pluripotency found in early embryos and ESCs

Front

What is a concern with the teratoma assay?

Back

Formation of tumors

Front

What is the most stringent test for pluripotency?

Back

Tetraploid Complementation Assay

Front

What happens when two embryos are fused in the Tetraploid Complementation Assay?

Back

All daughter cells are tetraploid

Front

What is the most common first choice for deriving iPSCs?

Back

Fibroblasts

Front

Which cell type is referred to as "The Chosen One" for iPSC generation?

Back

Keratinocytes

Front

What is a limitation of using blood cells for iPSC generation?

Back

Low efficiency

Front

What is a benefit of using keratinocytes for iPSC generation?

Back

Extreme convenience

Front

What can iPSCs be used for?

Back

Cancer Modeling