BIO2581B_S25_Tutorial_3_session_1

Front

What is a 'loss-of-function' mutation?

Back

A mutation that completely abolishes gene function.

Front

What type of mutation can result from incorporating 2-aminopurine in place of guanine during DNA replication?

Back

Transition mutation.

Front

How many genomes would you expect to have the sequence AGTCGGTCAACTACTGT in 10 double-stranded DNAs of random sequence 5x10^9 bases long?

Back

5.8 genomes.

Front

What is the minimum length of a query sequence expected to occur only once in a double-stranded genome 8x10^6 bases long?

Back

12 bases.

Front

What is the chance of finding the target sequence ATTCAGGATTCC in a double-stranded 100Mb genome?

Back

11.9%.

Front

Define 'transition mutation'.

Back

A mutation that replaces a purine with another purine or a pyrimidine with another pyrimidine.

Front

Define 'transversion mutation'.

Back

A mutation that replaces a purine with a pyrimidine or vice versa.

Front

What is the significance of base analogs in DNA replication?

Back

Base analogs can lead to mutations by being incorporated into DNA in place of normal bases.

Front

What is the role of double-stranded DNA in genetic information storage?

Back

Double-stranded DNA stores genetic information in the sequence of its bases.

Front

Explain the concept of 'indels' in genetics.

Back

Indels refer to insertions or deletions of bases in the DNA sequence.