Principles of Laboratory Animal Medicine

Slides 12 - 15

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Review!

Multiple Choice

Which of the following is NOT a requirement for animal use in teaching in Canada?

• Must follow all rules for animal use

• Must record all animals used

• Must evaluate the level to which animal is being used

• Must use only native Canadian species

Multiple Choice

What does GAP stand for?

• Good Animal Practice
• Guidelines for Animal Practices
• Good Animal Policy
• General Animal Protocol

Drag and Drop

CCAC stands for ​

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​

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on ​

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​

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Drag these tiles and drop them in the correct blank above

Canadian

Council

Animal

Care

Civic

Central

Committee

Conservation

Agricultural

Assessment

Slides 22-23

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Review!

Multiple Select

Which 3 of the following are critical considerations when selecting a species for research?

• Justify species

• Justify numbers used

• Justify protocol

• Justify funding sources

Open Ended

What are some questions we should ask when justifying a protocol?

Slides 29-32

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Review!

Multiple Choice

What is an example of an extrinsic factor that can predispose animals to disease?

• Heredity

• Lighting

• Food quality

• Drug effects

Multiple Select

Which 3 of the following are considered intrinsic factors that predispose animals to disease?

• Species

• Age

• Humidity

• Sex

Multiple Choice

What is an example of a "dietary" factor when it comes to stress factors for laboratory animal research?

• Lighting conditions in the lab
• Cleanability of plastic vs. metal food bowls

• Type of bedding used
• Temperature of the environment

Open Ended

What are the 4 stress factors?

Slides 38-40

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Review!

Match

Match the types of research

• Advancing fundamental knowledge of physical, chemical, and functional mechanisms of life processes and diseases

• Use of existing knowledge for solving a specific biomedical problem

• Always conducted on live animals, including humans

Basic

Applied

Clinical

• Basic

• Applied

• Clinical

Multiple Choice

Which type of research is primarily aimed at advancing fundamental knowledge of life processes and diseases?

• Basic Research

• Applied Research

• Clinical Research

• Experimental Research

Multiple Choice

Which of the following is a primary characteristic of applied research in biomedical science?

• It uses existing knowledge to solve specific problems.

• It always involves live human subjects.

• It does not use biomedical research models.

• It ignores species differences in research.

Review 54-56

Multiple Choice

What is a hypothesis?

• A definitive conclusion drawn from data.

• A random guess without any basis.

• Testable theory based on current knowledge.

• An untestable assumption about the future.

Multiple Choice

How many variables are tested in an experiment?

• One variable
• No variables
• Three variables
• Two variables

Final Review

Multiple Select

What are the 3 R's of animal use?

• Reduce

• Re-use

• Refine

• Recycle

• Replace

Match

Match the following

• Use statistical power analysis to determine the minimum number of animals needed for valid results.

• Employ computer modeling and simulations to predict biological responses.

• Use non-invasive imaging techniques (e.g., MRI) instead of surgical methods

Reduce

Replace

Refine

• Reduce

• Replace

• Refine

Drag and Drop

Designing a study where the same animals are observed over time instead of using separate groups is an example of ​

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Drag these tiles and drop them in the correct blank above

Reduce

Refine

Replace

Reuse

Drag and Drop

Administering analgesics and anesthetics appropriately during and after procedures is an example of ​

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Drag these tiles and drop them in the correct blank above

Refine

Replace

Recycle

Reuse

Reduce

Multiple Choice

Provide environmental enrichment like nesting materials and toys to reduce stress.

• Reduce

• Refine

• Replace

• Recycle

Multiple Choice

Why is it important to have principles and regulations in laboratory animal medicine?

• To ensure the safety and well-being of animals and humans

• To increase the cost of research

• To make experiments more difficult

• To delay scientific progress

Multiple Select

Which 3 statements about the CCAC are correct?

• It is a non-profit organization based in Ottawa.

• It sets and maintains standards for animal care in Canadian science.

• It was established in 1968.

• It is responsible for animal welfare in the United States.

Draw

Draw a cute mouse.