Week 14: Mutation Evaluation

​Mutation Evaluation!

Match

Match the following base pairs used during replication (DNA->DNA)

• Thymine (T)

• Cytosine (C)

• Adenine (A)

• Guanine (G)

Adenine (A)

Guanine (G)

Thymine (T)

Cytosine (C)

• Adenine (A)

• Guanine (G)

• Thymine (T)

• Cytosine (C)

Match

Match the following base pairs used during transcription (DNA->RNA).

• Adenine (A)

• Thymine (T)

• Cytosine (C)

• Guanine (G)

Uracil (U)

Adenine (A)

Guanine (G)

Cytosine (C)

• Uracil (U)

• Adenine (A)

• Guanine (G)

• Cytosine (C)

Multiple Choice

A mutation is defined as

• A temporary change in an organism's environment.
• A process of natural selection in evolution.
• A change in the DNA sequence of an organism.

• A random alteration in an organism's physical traits.

Multiple Choice

If a mutation occurs in an expressed gene, it will most directly affect the structure of a cell's

• nucleic acids
• carbohydrates
• lipids
• proteins

Match

Identify the correct point/gene mutation with its description.

• Insertion

• Deletion

• Substitution - Missense

• Substitution - Silent

• Substitution - Nonsense

A nucleotide is added

A nucleotide is removed

A single amino acid changes

No change in amino acid sequence

An amino acid changes to STOP

• A nucleotide is added

• A nucleotide is removed

• A single amino acid changes

• No change in amino acid sequence

• An amino acid changes to STOP

Hotspot

Identify where the difference in the DNA sequences is

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

Multiple Choice

Identify the type of mutation.

• Substitution - Silent

• Substitution - Missense

• Substitution - Nonsense

• Insertion

• Deletion

The next part is 6 questions where you will do each step in determining the type of mutation!

These are the steps you should follow each time when given a mutated DNA sequence.
Remember: You always have to compare to the orginal!

Multiple Choice

Original DNA: ATG CGA CCA

Original RNA: UAC GCU GGU

Original Amino Acids: Tyr Ala Gly

Mutated DNA: ACG CGA CCA

Mutated RNA: UGC GCU GGU

Mutated Amino Acids: Cys Ala Gly

Part 5: Identify the Type of mutation that occurred.

• Deletion

• Insertion

• Substitution - Missense

• Substitution - Nonsense

• Substitution - Silent

Congratulations!

• I can IDENTIFY they type of gene mutation and its effect on the amino acid sequence (protein chain)

• I can transcribe and translate and analyze the type of mutation and its effect on the amino acid sequence

Poll

How confident are you on these two learning targets?

I can IDENTIFY they type of gene mutation and its effect on the amino acid sequence (protein chain)

I can transcribe and translate and analyze the type of mutation and its effect on the amino acid sequence

• Not confident at all

• Somewhat confident

• Very confident