Tablets & Capsules

If the % compressiblity of a powder is 23-35%, the powder is _____ in flowability:

• Extremely poor

• Poor

• Fair

• Good

• Excellent

Erweka tester, Schleuniger tester, and Strong-Cobb tester are example of devices used to test:

• Tablet weight variation

• Tablet hardness

• Tablet disintegration

• Tablet dissolution

• Tablet content uniformity

The following factor/s can directly contribute to content uniformity problems in tablets:

I. segregation of the powder mixture or granulation during the various manufacturing processes

II. nonuniform distribution of the drug substance throughout the powder mixture or granulation

III. tablet weight variation

• I only

• III only

• I & II only

• II & III only

• I, II & III

The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet:

• Lamination

• Capping

• Sticking

• Picking

• Mottling

The unequal distribution of color on a tablet, with light or dark areas standing out in an otherwise uniform surface:

• Lamination

• Capping

• Sticking

• Picking

• Mottling

A term used to describe the surface material from a tablet that is sticking to and being removed from the tablet’s surface by a punch:

• Lamination

• Capping

• Sticking

• Picking

• Mottling

Tablet lamination or capping problems are often eliminated by:

I. Addition of colloidal silica to the formula

II. Slowing the tablet rate

III. Reducing the final compression pressure

• I only

• III only

• I & II only

• II & III only

• I, II & III

To overcome the mottling problem, the preventive measure is/are:

I. The formulator may change the solvent system

II. Change the binder system

III. Reduce the drying temperature

• I only

• III only

• I & II only

• II & III only

• I, II & III

“Arching” or “bridging” and “rat-holing” are problems associated with weight variation of tablets, specifically:

• Granule size and size distribution before compression

• Poor flow

• Punch variation

• Hardness variation

• Double compression

When the initial blend of powders is forced into the dies of a large-capacity tablet press and is compacted by means of a flat-faced punches, the compacted masses are called:

• Slugs

• Compaction rolls

• Tablet presses