Genomics and Bioinformatics

The first bioinformatics database was created by

• Richard Durbin

• Dayhoff

• Michael j.Dunn

• none of these

An example of Homology & similarity tool?

• PROSPECT

• RASMOL

• BLAST

• GENESCAN

If you were using a proteomics approach to find the cause of a muscle disorder, which of the following techniques might you be using?

• sequencing the gene responsible for the disorder

• developing physical maps from genomic clones

• determining which environmental factors influence the expression of your gene of interest annotating the gene sequence

• creating a genomic library

Human genome contains about

• 2 billion base pairs

• 3 billion base pairs

• 4 billion base pairs

• 5 billion base pairs

Shotgun cloning differs from the directed sequencing method in which of the following ways?

• The location of the clone being sequenced is known relative to other clones within the genomic library in shotgun cloning.

• making contigs

• The entire genome is sequenced in the clone-by-clone method, but not in shotgun sequencing.

• No genetic or physical maps of the genome are needed to begin shotgun cloning

IUPAC code V refers to

• Very large DNA

• Viruses

• A or G or T

• A or G or C

High throughput sequencing assembly and mapping of genes is called

• structural genomics

• Functional genomics

• Bioinformatics

• All of these

In a CML Patient gene "bcr" and "abl" are found on

• "bcr" on 9th chromosome and "abl" on 22nd chromosome

• "bcr" on 22nd chromosome and "abl" on 9th chromosome

• both "bcr" and "abl" on 9th chromosome

• both "bcr" and "abl" on 22nd chromosome

MIcroarray is used to study

• expression of many genes at a time

• presence of many genes at a time

• both expression and presence of many genes at a time

• none of these

Nick translation make use of

• DNA Polymerase 1 and DNA Polymerase 3

• DNA ligase 1 and DNA Polymerase 1

• DNase 1 and DNA Polymerase 1

• only DNA Polymerase 1