PHAR 7401 - The Biochemistry of Thrombosis (Clotting)

The extrinsic pathway and the intrinsic pathway both lead to the activation of factor X into factor Xa

• False

• True

Which of these factors are involved in the extrinsic pathway? Select all that apply.

• Factor III (Tissue Factor)

• Factor VII

• Factor VIII

• Factor IV (Ca2+)

• Factor X

Which of these factors are involved in the intrinsic pathway? Select all that apply.

• Factor XI

• Factor VIII

• Factor IV (Ca2+)

• Factor III (Tissue Factor)

• Factor IX

Select true or false in regards to the following order of events:

Prothrombin -> Thrombin -> Fibrinogen -> Fibrin

• False

• True

Streptokinase is an endogenous serine protease while t-PA is an enzyme released by a number of streptococcal bacterial strains.

• False

• True

Which of these following diseases involves the loss of factors (e.g. factor VIII, factor IX, and von Willebrand factor)? Select that apply.

• von Willebrand Disease

• Hemophilia A

• Hemophilia B

• non-Hodgkin's Lymphoma

• Osteosarcoma

Plasminogen is the main enzyme responsible for the degradation of fibrin clots.

• False

• True

Hemostasis is the stopping of bleeding; thrombosis is the process of repairing damaged endothelium in blood vessels.

• False

• True

The humoral factors (enzymes) of the clotting cascade activates in sequential order I to XIII to produce a clot?

• False

• True

In general, which type of enzyme is involved in the activation of a number of humoral clotting factors in the clotting cascade?

• Protease

• Kinase

• Nuclease

• Lipase

• Phosphotase