Flouroquinolones

Moxifloxacin from

• 1st generation

• 2nd generation

• 3rd generation

• 4th generation

IUPAC name of Ciprofloxacin

• 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolone carboxylic acid

• 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7(1-Pyrrolidinyl)-3-quinolone carboxylic acid

• 1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolone carboxylic acid

• 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-3-quinolone carboxylic acid

The addition of piperazine to the C-7 position improves activity against gram +ve organism

• True

• False

In Trovafloxacin have at position 1

Drug induced Photo-sensitivity is reduced by

• Fluoro substitution

• Methoxy substitution

• Amino substitution

• Phenyl substitution

Topoisomerase-II enzyme present in

• Gm +ve

• Gm -ve

• Both

• None of the above

Resistance in quinolones due to

• Altered affinity for enzyme

• Decreased uptake of drug

• Saturation of active site

• Energy dependent efflux mechanism

Quinolones used in

• Respiratory tract infection

• Meningitis

• Tuberculosis

• Viral Infection

Substitution control the pharmacokinetics

IUPAC name of Nalidixic acid

• 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine

• 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,7-naphthyridine

• 1-ethyl-1,4-dihydro-8-methyl-4-oxo-1,8-naphthyridine

• 1-cyclopropyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine