Genetics and the epigenome

Which of the following isn't a type of point mutation?

• Addition

• Deletion

• Inversion

• Substitution

Put a tick (✓) in the box next to the statement which describes incorrectly the effect of the mutation in an exon of a gene.

• A substitution may not result in a change to the encoded amino acid.

• An inversion will result in a change in the number of DNA bases.

• A deletion will result in a frame shift.

• An addition will result in a frame shift.

What is the name given to a non-coding section of a gene?

Gene mutations occur spontaneously. During which part of the cell cycle are gene mutations most likely to occur?

What is the impact of increased methylation of DNA?

• DNA coils more tightly

• DNA coils less tightly

• Nothing, as histones are methylated, not DNA

What is the impact of decreased acetylation of histones?

• DNA coils more tightly

• DNA coils less tightly

• Nothing as DNA are acetylated, not histones.

Which type of stem cell could be found in bone marrow?

• Totipotent

• Pleuripotent

• Multipotent

• Unipotent

Which type of stem cell are skin cells?

• Totipotent

• Pleuripotent

• Multipotent

• Unipotent

Which type of stem cell are found in a zygote?

• Totipotent

• Pleuripotent

• Multipotent

• Unipotent

Human pluripotent stem cells can form every type of cell except the cells from which organ?