HEMATOLOGY 2 MIDTERM EXAM

What intimal cell synthesizes and stores VWF?

• Smooth muscle cell

• Endothelial cell

• Fibroblast

• Platelet

What subendothelial structural protein triggers coagulation

through activation of factor VII?

• Thrombomodulin

• Nitric oxide

• Tissue factor

• Thrombin

What coagulation plasma protein should be assayed when

platelets fail to aggregate properly?

• Factor VIII

• Fibrinogen

• Thrombin

• Factor X

What role does vitamin K play for the prothrombin group

factors?

• Provides a surface on which the proteolytic reactions of

  the factors occur

• Protects them from inappropriate activation by compounds

  such as thrombin

• Accelerates the binding of the serine proteases and their

  cofactors

• Carboxylates the factors to allow calcium binding

Coagulation factor VIII circulates bound to:

• VWF

• Factor IX

• Platelets

• Factor V

Normal hemostasis depends on all of the following except

• an intact vascular system

• inadequate numbers of platelets

• appropriate coagulation factors

• fibrinolysis

Which blood vessels have the thickest walls?

• Veins

• Arteries

• Capillaries

• Arterioles

The initiating stimulus to blood coagulation following

injury to a blood vessel is

• contact activation with collagen

• vasoconstriction

• stenosis

• release of serotonin

Which of the following is not correct?

• Vasoconstriction reduces blood flow and promotes

  contact activation of platelets and coagulation factors

• Platelets adhere to exposed endothelial connective

  tissues

• Aggregation of platelets releases thromboxane A2

  and vasoactive amines (serotonin and epinephrine)

• None of the above

• All of the above

Which of the following is (are) true of thrombopoietin?

• Thought to stimulate the production and maturation

  of megakaryocytes

• Is influenced by various cytokines, which increase

  megakaryocyte size

• Is influenced by various cytokines, which impact

  maturational stage and ploidy

• All of the above

• None of the above