Synthetic Design

Which of the following statements best describes retrosynthesis?

• The reaction conditions required to convert the product of a reaction back to the original starting materials

• A strategy used to design a synthesis of a target molecule by working back from the target to simple starting materials

• he design of a synthetic scheme using cheap, traditional reagents, rather than expensive modern reagents

• The design of reaction conditions such that an equilibrium reaction is pushed towards the products rather than the starting materials.

Which of the following statements best describes a disconnection in retrosynthesis?

• A disconnection involves a theoretical disconnection of a bond in a target structure in order to identify simpler structures that could be linked through the formation of that bond

• A disconnection involves identifying stages where a bond is split in the corresponding synthesis.

• A disconnection identifies retrosynthetic stages which would not be feasible in the corresponding synthesis

• A disconnection describes the reaction conditions required to split a target structure into simpler molecules.

Which of the synthons (A-D) represents the following reagent?

• 
• 
• 
• 

Which of the following synthons is an example of Umpulong ?

• 
• 
• 
• 

Berikut merupakan umpolung dari sinton positip C pada C=O dalam molekul RCOH atau CH₃COH, kecuali

• 
• 
• 
• 

Berikut adalah pasangan ekivalen sintetik hasil diskoneksi yang sesuai dengan well approach untuk molekul target berikut CH₃CH₂CH(CH₂CH₃)COOH, kecuali

• CH₃CH₂CH₂COOCH₂CH₃ + CH₃CH₂Br

• CH₂(COOCH₂CH₃)₂ + 2 CH₃CH₂Br

• CH₂(COOH)₂ + 2 CH₃CH₂Br

• CH₂=C(CH₂CH₃)COOCH₂CH₃ + CH₃MgBr

Berikut adalah satu langkah mundur dengan bantuan FGI untuk mendapatkan molekul target Ph-NH₂, kecuali

• Ph-NO₂

• PhCONH₂

• PhCONH₂

• PhCN

Terhadap senyawa nitrobenzena dilakukan serangkaian reaksi berikut: (i) LiAlH₄; (ii) CH₃COCl/AlCl₃; dan (iii) suatu epoksida (lihat gambar berikut). Produk sintesis yang dihasilkan adalah

• 
• 
• 
• 

Senyawa fenol mengalami serangkaian reaksi berikut: (i) CH₃Cl/AlCl₃; (ii) KMnO₄; (iii) Br₂/Fe dan (iv) CH₂=CH–CN. Produk sintesis yang dihasilkan adalah

• 
• 
• 
• 

Dilakukan serangkaian reaksi berikut terhadap senyawa toluena: (i) Cl₂/FeCl₃; (ii) HNO₃/H₂SO₄; (iii) H₂/Pd,C; (iv) NaNO₂/HCl; dan (v) Cu(I)CN. Produk sintesis yang dihasilkan adalah

• 
• 
• 
•