Advance MU Part 2

How to validate that imprecision for both IQC and human samples is similar?

• Compared variance using F-Test

• Do Lot-to-lot reagent verification

• Partition the IQC that have shift or significant change

• Assuming by eye ball

Partition of IQC data need to calculate separately due to

• QC lot that cause a significant shift in QC value without change in patient sample

• Insufficient data for long term interval of IQC

• Change of calibrator lot

• MU not fit the purpose

What is formula of MU estimation when bias is not include in calculation

• u = √ (u_Rw² + ucal² + uBias²)

• u = √ (u_Rw² + ucal²)

• u = √ (u_Rw² )

• All of above

Uncertainty due to bias correction, u_bias is rarely include in MU calculation due to (more than 1 answer)

• Limitation of bias calculation using EQA bias

• The laboratory applying correction factor

• Small changes in bias will be captures by long term precision

• All above

Reporting of MU more consistent across concentration intervals using this

• Absolute uncertainty (u)

• Long term precision, U_RW

• Relative uncertainty , Urel

• Calibrator uncertainty, Ucal