ISBP 2B cell membrane stability inhibitors

Lipopeptides- Daptomycin

gram-negative

• yes

• no

Lipopeptides- Daptomycin

anaerobic

• yes

• no

Lipopeptides- Daptomycin

Interactions - statins

• yes

• no

Lipopeptides- Daptomycin

use to treat pneumonia

• yes

• No

Polymyxins-Colistin

Gram-positive coverage

• Yes

• No

Polymyxins-Colistin

Gram-negative (including Proteus sp.)

• Yes

• No

Polymyxins-Colistin

Gram-negative (except Proteus sp.)

• Yes

• No

Polymyxins-Colistin

anaerobic

• Yes

• No

Polymyxins-Colistin

adverse effects

• GI distress

• nephrotoxicity, neurotoxicity

• headache, migrane

Polymyxins-Colistin

Pk

• IV/IM formulation ok for inhalation

• IV/IM formulation sometime is ok for inhalation

• IV/IM formulation is not ok for inhalation