PHA 051 P1 LEC & LAB

 

The following may affect drug metabolism, EXCEPT:

• Race

• Age

• Gender

• Social Status

 

Dimercaprol is a chelating agent used in the treatment of:

• Arsenic poisoning

• Lead poisoning

• Iron poisoning

• Vanadium poisoning

An important protein that binds most of the basic drugs:

• Alpha1-acid glycoprotein

• Albumin

• Globulin

• Transferrin

The phenol derivative used as toothache drops:

• Thymol

• Eugenol

• Chlorocresol

• Cresol

 

Which of the following statements describe pharmacodynamic process?

• I, II, and III

• II, III, and IV

• I, III, and V

• III, IV, and V

What are bioisosteres?

• Functional groups which have similar spatial and electronic character, but they retain the activity or parent.

• Substituents or groups with similar physical or chemical properties that impart similar biological properties to a chemical compound.

• Enhance the desired biological or physical properties of a compound without making significant changes in chemical structure

• All of the choices

 

The phenol derivative extracted from the oil of Thymus vulgaris:

• Isopropyl-m-cresol

• 4-chloro-3-methoxyphenol

• 4-chloro-2-methoxyphenol

• p-chloro-m-xylenol

 

Evaluate the following statements regarding preservatives:

• Only statement I is correct.

• Only statement I and II are correct

• Only statement I and III are correct

• Only statement II and III are correct

The most important enzyme system of phase I metabolism is cytochrome P-450 (CYP450). CYP450 enzymes can be induced or inhibited by many drugs causing drug interactions in which one drug may reduce the therapeutic effect of another drug or enhance the toxicity of the other drug

• Only the 1st statement is CORRECT.

• Only the 2nd statement is CORRECT.

• Both statements are CORRECT.

• Both statements are INCORRECT.

Both statements are INCORRECT.

• Lipophilic medium

• Hydrophobic medium

• Hydrophilic medium

• None of the choices