344 Complement

What is the main goal of inflammation?

• to represent a pathological response to bacteria

• the body's way of asking for antibiotics

• to restore immune homeostasis

• to feel pain, and heat

Which of the following is NOT an important pro-inflammatory cytokine

• IL-10

• IL-1

• TNF-a

• IL-6

What makes the classical complement pathway a part of both the innate and adaptive immune response?

• It includes lectins and ficolins

• It includes antibodies and C1 complex

• It gets stronger with each additional exposure to the target

• It is slow

What is the common enzyme that initiates the complement cascade in all three complement activation pathways

• C3a

• C5b

• C5 convertase

• C3 convertase

Which complement pathway can be spontaneously activated by C3 hydrolysis?

• Classical pathway

• alternative pathway

• lectin pathway

• ficolin pathway

Which terminal complement protein initiates MAC?

• C3a

• C3b

• C5a

• C5b

Which complement protein initiates phagocytosis by binding to CR1 on macrophages?

• C3a

• C3b

• C5a

• C5b

What is the main effector mechanism of complement?

• Phagocytosis

• inflammation

• MAC

• all of the above

Which of the following is a positive regulator of the complement cascade?

• factor P

• factor H

• factor B

• all of the above