Rosukem / Rosukem-EZ

Rosukem EZ approved by following Agencies

• Lipids association of India

• Europeans society of Cardiology

• American associan of Clinical Endocrinilogists.

• ACC/AHA

• CSI

Rosukem EZ gives Z+ protection in following Patients

• statin intolerant patient

• T2DM

• Hypercholesteremia

• ASCVD

Rosukem EZ offers

• LDL-C goal achievement in 91% patients

• 15% more LDL -c reduction than monotherapy

• Prevents Cardiovascular events even at the age of 75 or more

• Reduce 13% more Plaque volume.

latest Brand SKU of Rosukem is

• Rosukem F

• Rosukem CV

  Rosukem A

• Rosukem Gold

• Rosukem EZ

• Rosukem 5/10/20

Indication for Rosukem EZ is

• For CVD prevention in patient with hypercholesterolemia

• For CVD prevention in T2DM patients

• For CVD prevention post PCI / CABG

• Patients who are unable to achieve LDL-C goal despite of statin monotherapy

• For secondary prevention of ASCVD

MOA of Rosukem

• ●inhibits HMG CoA reductase enzyme in liver

• ●It  binds and blocks the mediator of cholesterol absorption, Niemann-Pick C1-Like 1 (NPC1L1) transporter protein on epithelial cells of intestinal tract

• Blocks alpha Glucosidase Receptor

• Block sulphonamide receptor in b-cells

MOA Rosukem EZ

• ●It  binds and blocks the mediator of cholesterol absorption, Niemann-Pick C1-Like 1 (NPC1L1) transporter protein on epithelial cells of intestinal tract

• ●inhibits HMG CoA reductase enzyme in liver

• Reduces HGO, increases Insulin sensitivity

  peripheral utilization of glucose.

• Induces PPAR - gamma & alpha

Rosuvastatin is most extensively studied statin with

• 18 clinical trials & 63000 Patients

• 20 clinical trials & 65000 Patients

• 15 clinical trials & 60000 Patients

• 17 clinical trials & 62000 Patients

• 19 clinical trials & 64000 Patients

Rosukem is superior to Atorvastatin in following parameters.

• Hepatoselectivity, Hydrophilicity

• reduces total Arethoma value by -6.3 compared to -4.4 of high intensity Atorvastatin.

• superior to atorvastatin in the reversion of coronary atherosclerotic plaques

• ●Increase fibrous cap thickness and decreases macrophages line arc

• better reduction of LDL-c

Rosukem EZ SKU are

• Rosuvastatin 10 mg + Ezetimibe 10 mg

• Rosuvastatin 5mg + Ezetimibe 10 mg

• Rosuvastatin 40 mg + Ezetimibe 10 mg

• Rosuvastatin 20 mg + Ezetimibe 10 mg