Allergic Response Quiz

Example of a deficiency in an inhibitor of the C1 complement system

• Hereditary (autosomal dominant) angioedema

• Acquired angioedema associated with lymphoma

• Acquired angioedema associated with lymphosarcoma

• Acquired angioedema associated with chronic lymphatic leukemia

• All are examples of a deficiency in an inhibitor of the C1 complement system

Hypersensitivity reaction is independent of complement activation

• Type I and IV

• Type II and Type III

• Type II and Type IV

• Type I and III

A patient was undergoing a series of surgical procedures requiring general anesthetic. At the third procedure he suddenly became hypotensive with marked cardiac arrhythmia. In addition his breathing became difficult due to extensive bronchocorstriction and obstructive laryngeal edema. Despite the efforts of the surgical team the patient developed severe and permanent brain damage due to hypoxemia. It was subsequently discovered that the patient had developed IgG antibodies to the anesthetic gas and this had resulted in an anaphylactoid response to the anesthetic. What type of reaction caused this condition?

• Type I

• Type II

• Type III

• Type IV

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The ability of this organism to cause disease is related to it’s ability to infect, persist  in, and replicate within macrophages. The lepromin skin test is used to determine what type of leprosy a person has. In this test, inactivated Mycobacterium leprae organisms are injected just beneath the skin. At the site of injection, a person with a positive test will develop an area of induration with erythema peaking around 48 hours after the injection. If this test measures a hypersensitivity reaction against the organism, what type of hypersensitivity reaction is it intended to detect?

• Type I

• Type II

• Type III

• Type IV

The principle difference between type II and type III hypersensitivity is

• The class (isotype of antibody)

• Whether the antibody reacts with the antigen on the cell or reacts with antigen before it interacts with the cell

• The participation of complement

• The participation of T cells

How is this reaction probably mediated by? A child stung by a bee experiences respiratory distress within minutes and lapses into unconsciousness.

• IgE antibody

• IgG antibody

• Sensitized T cells

• Complement

A patient with severe asthma gets no relief from antihistamines. The symptoms are MOST likely to be caused by:

•  IL-2

•  Leukotrienes

• Serotonin

• Bradykinin

   

Hypersensitivity to penicillin and hypersensitivity to poison oak are both:

• Mediated by IgE antibody

• Mediated by IgG and IgM antibody

• Initiated by haptens

• Initiated by Th2 cells

Which of the following regarding anaphylactic (type I) and immune complex (type III) hypersensitivities is the most accurate?

• IgE is involved in both anaphylactic and immune complex hypersensitivity.

• Complement is involved in both anaphylactic and immune complex hypersensitivities.

• Less antigen is typically needed to trigger an anaphylactic reaction than an immune complex reaction

• Neutrophils play a more important role in anaphylactic reactions than in immune complex reactions.

A delayed hypersensitivity reaction is characterized by:

• Edema without a cellular infiltrate

• An infiltrate composed of neutrophils

• An infiltrate composed of helper T cells and macrophages

• An infiltrate composed of eosinophils