Bacterial Protein Synthesis Inhbitors

Which of the following adverse effects is often

employed as a therapeutic use for erythromycin?

• QTc prolongation

• Increased gastrointestinal motility

• Photosensitivity

• Deposition in bone

Answer explanation

Erythromycin is a motilin receptor agonist & is often used for the short term treatment of gastroparesis or paralytic ileus

After 5 days of clindamycin treatment for a skin

infection, a patient develops diarrhea (10 watery

stools/day), severe abdominal pain, and fever.

Which of the following drugs could not be given as treatment for this patient?

• Vancomycin

• Fidoxamicin

• Ceftriaxone

• Metronidazole

Which of the following statements accurately

describes the difference in spectrum of activity

between erythromycin and azithromycin?

• Azithromycin has better activity against respiratory

  pathogens such as Haemophilus influenzae

  and Moraxella catarrhalis but less potent activity

  against staphylococci and streptococci.

• Erythromycin has the same activity as azithromycin

  against gram-positives and gram-negatives

• Azithromycin has better activity against staphylococci

  and streptococci compared to

  erythromycin

• Erythromycin has better activity against

  gram-negatives such as H. influenza.

Linezolid would be a good choice for antibiotic

treatment in which of the following patient

scenarios?

• Bacteremia caused by Staphylococcus aureus

• Urinary tract infection caused by Escherichia coli

• Pneumonia caused by drug-resistant

  Streptococcus pneumoniae

• Diabetic foot infection caused by Pseudomonas

  aeruginosa

Which of the following antibiotic agents should not

be given to children less than 8 years of age due to

its deposition in bone and teeth?

• Azithromycin

• Quinupristin/dalfopristin

• Doxycycline

• Linezolid

A 77-year-old woman was started on antibiotics

for pneumonia treatment. After 3 days of antibiotic

therapy, the serum creatinine doubled. Which of the

following antibiotics is most likely responsible for

this increase in serum creatinine?

• Doxycycline

• Linezolid

• Tobramycin

• Clarithromycin

Which antimicrobial can cause Gray Baby syndrome?

Aminoglycosides are commonly used for their

concentration-dependent bactericidal activity

against which group of organisms?

• Gram-positive aerobes

• Gram-negative aerobes

• Gram-positive anaerobes

• Gram-negative anaerobes

A routine screening nasal swab done in asymptomatic health care workers in a hospital ICU has turned up positive for MRSA in two of them. Which of the following drugs can be used topically to eradicate the organism?

• Vancomycin

• Linezolid

• Fidoxamicin

• Mupirocin

All bacterial protein synthesis inhibitors are bacteriostatic except

• Tetracylines

• Aminoglycosides

• Linezolid

• Azithromycin