Test 11 MDS continued

Match the following MDS classifications

• Refractory cytopenia with unilineage dysplasia

• RCMD

• associated with isolated del(5q)

• RCUD

• refractory anemia with ringed sideroblasts

• RARS

• Refractory anemia with excess blasts

• RAEB

• Refractory cytopenia with multilineage dysplasia

• MDS

Refractory cytopenia with unilineage dysplasia (RCUD) characteristics

Only ​ (a)   line typically affected

Refractory anemia: ​ (b)   of all MDS cases

Refractory ​ (c)   and refractory ​ (d)   : only ​ (e)   of all MDS cases

• one cell
• 10-20%
• neutropenia
• thrombocytopenia
• 1-2%
• two cell
• 20-30%
• 2-3%
• thrombocytosis
• neutrocytosis

Choose all RCUD characteristics of Peripheral blood.

• rare or no myeloblasts (<1%

• Hypercellular; <5% myeloblasts

• <15% ring sideroblasts

• decrease in affected cell line

Choose all RCUD characteristics of Bone Marrow.

• <5% myeloblasts

• Hypercellular;

• <15% ring sideroblasts

• decrease in affected cell line

Which of these is not a characteristic of Peripheral blood found in RCMD?

• rare or no blasts (<1%)

• variable % of ring sderoblasts

• No Auer rods

• decrease in affected cell lines

Which of these is not a characteristic of Bone marrow found in RCMD?

• rare or no blasts (<1%)

• variable % of ring sderoblasts

• Hypercellular

• <5% blasts

Which disease has these characteristics 30-40% of all MDS cases,

bicytopenia or pancytopenia, and associated with complex CHR abnormalities.

• Refractory anemia with excess blasts

    (RAEB)

• Refractory anemia with ringed sideroblasts (RARS)

• Refractory cytopenia with multilineage dysplasia (RCMD)

• Refractory cytopenia with unilineage dysplasia (RCUD)

Characteristics of RARS-Refractory Anemia with Ring Sideroblasts

​ (a)   of all MDS cases (not the most common)

Only ​ (b)   lineage affected

Anemia is the ​ (c)  

PB

​ (d)   : ​ (e)   macrocytes/micro-hypo

<1% blasts

• 5-10%
• erythroid
• main symptom
• Dimorphic RBC
• oval
• least symptom
• Dimorphic WBC
• square
• 1-5%

Characteristics of RARS-Refractory Anemia with Ring Sideroblasts

BM

​ (a)  

Megaloblastoid dyserythropoiesis

​ (b)  

>15% ​ (c)  

​ (d)   causes should be ruled out

• Hypercellular
• <5% myeloblasts
• ring sideroblasts
• Secondary
• Primary
• Hypocellular
• >5% myeloblasts
• ring myeloids

In Refractory Anemia with Excess Blasts (RAEB) the other most common MDS which of these is not a characteristic of Peripheral Blood.

• Dyshematopoiesis in all cell lines

• Normo-or slightly macrocytic RBCs

• up to 19% myeloblasts, Auer rods may be present

• Cytopenia in at least 2 cell lines

• Qualitative abnormalities in all