WOUND HEALING

Stages of wound healing

• 1. Hemostasis

  2. Reactive

  3. Remodelling

  4. Maturation

• 1. Hemostasis

  2. Inflammation

  3. Reepithelisation

  4. Remodelling

• 1. Hemostasis

  2. Proliferation

  3. Reactive

  4. Maturation

• 1. Hemostasis

  2. Inflammation

  3. Reparative

  4. Maturation

First 24 hours of wound healing,

• Collagen begins to accumulate

• Neutrophils appears at margin of incision

• Contraction of the wound

• Angiogenesis occur

• vascular constriction occur

Growth factors involved in wound healing include

• Platelet Derived Growth Factor (PDGF)

• Fibroblast Growth Factor

• Transforming Growth Factor Beta

• Epidermal Growth factor

• Tumour Necrosis factor (TNF)

Healing by second intention differs from first intention by

• Less scarring

• More intense inflammatory reaction

• Inability of wound margins to oppose

• Delayed primary closure

Goal of surgical procedure should be

The following adversely affect wound healing :

• Diabetes Mellitus

• Advanced age

• Zinc deficiency

• Corticosteroid excess

Early complication of wound healing

• Hematoma

• Keloid formation

• Ulceration

• Wound dehiscence

Which of the following is true regarding keloid

• 
• Keloid: More often in light-skin people

• Keloid: raised beyond boundary of the wound

• 

Regarding surgical wound

• Contaminated wound infection rate >10%

• Inguinal hernia repair is clean procedure

• Contaminated wound: GI and respiratory tract entered without spillage

• Wound recovered 90% original strength in 3 months