Immune Tolerance & Autoimmunity

After exiting the thymus, mature T cells are subjected to the secondary selection where the majority of self-reactive T cells are deleted or rendered anergic.

The process is known as...........................?

• Central tolerance

• Peripheral tolerance

• Immune activation

• Clonal activation

Certain autoimmune disorders are monogenic-caused by a mutation in a single gene.

The following are the monogenic autoimmune disease, Except?

• Autoimmune lymphoproliferative syndrome

• Autoimmune polyadenopathy

• Immunodysregulation polyendocrinopathy (X-linked)

• Systemic Lupus Erythematosus

The autoimmune disorder with an elevated anti-thyroglobulin antibody is known as....................................?

• Hashimoto thyroiditis

• Grave's disease

• Goodpasture syndrome

• Celiac disease

The presence of anti-glutamic acid decarboxylase antibodies increased the susceptibility to which of the following disorder?

• Type 1 Diabetes mellitus

• Celiac disease

• Grave's disease

• Pernicious anemia

In 'Rheumatic fever ', the cross-reactivity between the bacterial M protein and human lysoganglioside leads to the development of cardiac T cells. 

M protein is a cell wall component of........................................?

• Staphylococcus aureus

• Streptococcus pyogenes

• Hemophilus influenzae

• Neisseria gonorrhoeae

The generation of reactive cells against HHV-6 encoded U24 cross-reactive with myelin basic protein resulting in autoimmune disease

• Myasthenia gravis

• Grave's disease

• Multiple sclerosis

• Systemic Lupus Erythematosus

'Myasthenia Gravis' is caused by the production of autoantibodies against the..................................?

• Myelin basic proteins

• TSH receptor

• Acetylcholine receptor

• Thyroglobulin

What is immunological tolerance?

• The ability of the immune system to produce only lymphocytes that recognize self-antigen

• The ability of the immune system to remove lymphocytes that recognize foreign antigen

• The ability of the immune system to recognize foreign germs and attack them

• The ability of the immune system to recognize self from non-self or altered self