Medicinal Biochemistry- Mechanism of enzyme action & Co-enzymes

Which of the following statement is worng regarding mechanism of enzyme action

• Catalysis is the primary function

• Enzymes reduces the activation energy

• Enzymes increases the activation energy

• formation of Enzyme substrate complex is cruical in enzyme action

Who proposed Lock & key model of enzyme action and its limitation

• EMil fisher & active site is flexible

• Emil fisher & active site is rigid, pre-shaped templates.

• Emil fisher & allosteric effect is explained

• Emil fisher & allosteric effect is not explained

What is the evidence for Induced fit theory or Koshlands model

• allosteric model

• X- ray diffraction

• UV rays theory

• Spectral quantity theory

Protonation and conjugation of histidine comes under which mechanism of enzyme catalysis

• Acid-base catalysis

• substrate strain

• covalent catalysis

• entropy catalysis

name the mechanism of enzyme catalysis in which the enzyme is present in the secreation of pain sensations secreted from eyes

• lysozyme

• acid-base catalysis

• substrate strain catalysis

• both B & C

The positive & negative charges at active site is involved in which mechanism of catalysis with example

• Substrate strain catalysis

• Acid-base catalysis

• Covalent catalysis & Trypsin

• Covalent catalysis & tears

In which mechanism of catalysis disorder of a system takes place

• Enthalpy effect

• Substrate strain catalysis

• Acid-base catalysis

• Entropy effect

what is the unit of enyme & 1 IU is equal to

• Katal & 50 mcIU

• Katal & 60 mckatal

• IU & 1.67nkatal

• none of the above

name the derivative of coenzyme which transfers aldehyde or keto

• TPP

• Thiamine pyophosphate

• Thiamine

• both A & B

Which of the following non vitamin B complex coenzyme is helpful in glycogen synthesis

• ATP

• CDP

• UDP

• TPP