PK Exam 2: drug elimination CL & Renal CL (1-25)

Irreversible removal of drug from the body by all routes of elimination.

• Metabolism

• absorption

• elimination

The declining plasma drug concentration observed after systemic drug absorption shows:

• the drug is being eliminated from the body

• the difference between distribution and elimination

• which elimination processes are involved

Answer explanation

declining plasma concentration does not give insight to which elimination processes are involved or the difference between distribution and elimination.

It only shows that drug is decreasing in the plasma.

Which one?

• one com IV bolus

• two com IV bolus

Answer explanation

We know it's a 2 compartment because it's distributing into the periphery

Which one?

• one com IV bolus

• two com IV bolus

Answer explanation

There is no distribution into the periphery => one compartment

Which drugs are excreted mainly by renal excretion?

• volatile

• nonvolatile

• nonpolar

• polar

Drug excretion is removal of intact, unchanged drug.

• True

• False

Select all of the pathways for drug excretion.

• vile

• sweat

• saliva, milk, other body fluids

• lungs

• renal

Answer explanation

volatile drugs excreted through the lungs

process by which the drug is chemically converted in the body to metabolite

• drug excretion

• biotransformation

Answer explanation

usually an enzymatic process

Biotransformation always involves enzymes

• True

• False

Answer explanation

Usually enzymatic but not always (ester hydrolysis)

Where are the enzymes involved in biotransformation of drugs mainly located?

• kidney

• liver

• blood