Medicinal Biochemistry- Krebs , HMP pathway & Gluconeogenesis

Which of the following statement is correct regarding Krebs cycle-

a. Krebs cycle purely happens in Mitochondrial matrix

b. The total reactions occur in krebs cycle is 10

c. The number of enzymes requried for Glycolysis is 10

d. For all the reactions of Krebs cycle ATP is the only energy source

• A & B

• A & C

• B & C

• C & D

What are the enzymes that carry out two reactions

• Pyruvate kinase

  &

  Aconitase

• Aconitase

  &

  Isocitrate dehydrogenase

• Isocitrate dehydrogenase

  &

  Malate dehydrogenase

• Malate dehydrogenase &

  Succinate thiokinase

Number of CO2, NADH, FADH2 Produced in Krebs cycle for one glucose molecule is

• 2, 3, 1

• 1, 2, 3

• 4, 6, 2

• 2, 4, 6

What is the purpose of HMP shunt pathway

• Pentose sugars

  &

  NADH generation

• Pentose sugars

  &

  NAD+ Generation

• Hexose sugars

  &

  NAPDH generation

• Pentose sugars

  &

  NADPH generation

if 6 molecules of G-6-P enters into HMP pathway number of G-6-P exit is

• 2

• 3

• 4

• 5

Name the eznyme in HMP pathway where its action seen for 2 times

• Transketolase

• Transaldolase

• epimerase

• Isomerase

In gluconeogenesis, the conversion of pyruvate to PEP requires

• CO2

• ATP

• GTP

• all the above

Which of the following substrate used in gluconeogenesis is called as cori cycle

• Glycerol

• Glucogeneic amino acids

• Lactate

• Propionates

Which of the following amino acids will form the Odd chain fatty acids upon oxidation

• Phenylalanine

  &

  Isoleucine

• Aspartate

  &

  Isoleucine

• Methionine

  &

  Aspartate

• Methionine

  &

  Isoleucine

Which of the following is the biotin dependent mitochondrial enzyme

• Pyruvate decarboxylase

• PEPcarboxykinase

• Pyruvate carboxylase

• PEP decarboxykinase