Anthracycline

What is the mechanism of action of anthracyclines involving enzyme interaction?

• Inhibition of DNA polymerase

• Inhibition of RNA polymerase

• Inhibition of topoisomerase-II

• Inhibition of topoisomerase-I

What is the maximum cumulative dose of Doxorubicin in mg/m²?

• 900

• 450-550

• 800

• 140

What is the primary method of administration for anthracyclines?

• Subcutaneous

• Intravenous

• Intramuscular

• Oral

Which of the following is NOT a side effect of anthracyclines?

• Hypertension

• Tissue necrosis

• Peripheral neuropathy

• Elevated hepatic enzymes

What is the antidote used for anthracycline extravasation that can be used topically?

• Dexrazoxane

• Potassium

• Iron

• DMSO

What is the recommended action in case of acute cardiac symptoms during anthracycline infusion?

• Increase infusion rate

• Stop infusion and go to the ER

• Continue infusion

• Refer to cardiologist

Which of the following is NOT a contraindication for anthracycline therapy?

• Pregnancy

• Renal impairment

• Pre-existing cardiac conditions

• Hypersensitivity