Proteins and Mutations

Organize all the steps a cell takes to make a protein from beginning to end.

(Part 1)

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Organize all the steps a cell takes to make a protein from beginning to end.

(Part 2)

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In class we made a metaphor for how making proteins is like making a product.

Match each cell part with what it acts like

• mRNA

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• Amino Acids

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• Protein

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• tRNA

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• Ribosome

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What is a mutation?

• A mutation is a type protein inside a cell

• A mutation is a disease that people can get

• A mutation is a new strand of DNA made in a baby

• A mutation is a change in the DNA sequence of an organism.

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What can a mutation cause in a cell?

• It can make a protein be built the wrong way

• It can make a protein be the wrong shape

• It can stop a protein from being made at all

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The shape or ​ (a)   of a body part is very important for it to be able to do its job or ​ (b)  

• structure
• function
• color
• size
• design
• purpose

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In sickle cell disease a mutation in the DNA causes a change in which molecule?

• glucose
• insulin
• cholesterol
• hemoglobin

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How does the mutation change how the hemoglobin works inside the red blood cell?

• It makes the Hemoglobin stick to itself in rods

• It makes it easier for the Hemoglobin to hold onto oxygen

• It makes the Hemoglobin much larger and swells the cell

• It makes the hemoglobin turn blue instead of yellow

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How does this mutation change the red blood cell?

The sticky hemoglobin forms rods which . . .

• makes the cell a sickle or half moon shape

• makes the cell a spikey ball shape

• makes the cell completely flat

• makes the cell into a square shape

Because the mutation ​ (a)   the protein, it affected the ​ (b)   of the red blood cell. That, in turn prevents it from doing its ​ (c)   of delivering oxygen to the body because it gets caught in the ​ (d)   and makes blockages.

• changed
• structure
• function
• blood vessels

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