Understanding Autoimmune Disease Risks in Women

What is the ratio of women to men for lupus?

• 4 to 5

• 19 to 1

• 9 to 1

• 24 to 50 million

Which molecule is responsible for X-chromosome inactivation?

• RNA

• Xist

• DNA

• Protein

How many Americans have an autoimmune disease?

• Between 24 and 50 million

• Over 100 million

• Approximately 75 million

• Less than 10 million

What percentage of autoimmune disease patients are women?

• More than 90%

• Less than 30%

• Exactly 50%

• Up to 80%

What is the role of Xist in female cells?

• Activates Y chromosome

• Shuts down one X chromosome

• Produces proteins

• Generates antibodies

What does the presence of two X chromosomes in females risk?

• Underproduction of proteins

• Overproduction of proteins

• No risk at all

• Production of Y chromosome

What is the ratio for Sjogren’s syndrome?

• 1 to 9

• 4 to 5

• 19 to 1

• 9 to 1

What type of molecule is Xist classified as?

• lncRNA

• tRNA

• mRNA

• rRNA

What triggers the immune response leading to autoimmune disorders in women?

• Xist/protein/DNA complexes

• Y chromosome

• Underactive X chromosome

• Overactive immune system

What is required along with Xist activation for autoimmunity to develop?

• Overproduction of proteins

• Underproduction of RNA

• Absence of Y chromosome

• Tissue-damaging stress