Quiz on ADAMTS13 and von Willebrand Factor

What is the normal biochemical function of ADAMTS13?

• To cleave large von Willebrand factor (vWF) multimers, preventing excessive platelet aggregation.

• To promote clot formation by aggregating platelets.

• To create antibodies that attack platelets.

• To produce large quantities of hemoglobin.

How does ADAMTS13 regulate von Willebrand factor (vWF)?

• By speeding up platelet aggregation in injured vessels.

• By breaking down large vWF multimers, reducing platelet aggregation.

• By binding to hemoglobin and controlling oxygen transport.

• By turning platelets into mini-drones for immune surveillance.

What happens when ADAMTS13 is deficient?

• vWF levels rise, causing increased clot formation.

• Large vWF multimers accumulate, causing uncontrolled platelet aggregation and microthrombi formation.

• Hemoglobin levels spike, leading to excessive oxygen delivery.

• The patient becomes resistant to mosquito bites.

How does the immune system change to destroy ADAMTS13 in acquired TTP?

• It produces IgG autoantibodies that inhibit ADAMTS13.

• It signals macrophages to eat all the ADAMTS13 enzymes.

• It increases ADAMTS13 production to enhance platelet activity.

• It converts ADAMTS13 into platelets for extra blood clotting.

What are common triggers for the autoimmune destruction of ADAMTS13?

What is the role of autoantibodies in acquired TTP?

• They bind to ADAMTS13, blocking its function.

• They stimulate red blood cell production.

• They destroy vWF directly.

• They cause spontaneous platelet explosions.

What happens when ADAMTS13 is neutralized by autoantibodies?

• Large vWF multimers accumulate, leading to abnormal platelet aggregation.

• Platelets become unable to function, causing endless bleeding.

• The patient develops superhuman healing abilities.

• vWF becomes inactive, causing the body to dissolve all clots instantly.

How does plasmapheresis help in treating acquired TTP?

• It removes autoantibodies against ADAMTS13 and replaces deficient enzyme.

• It floods the body with platelets to overwhelm the immune system.

• It transforms plasma into red blood cells.

• It temporarily suspends gravity to prevent clotting.

Name the blood cells, whose reduction in number can cause clotting disorder, leading to excessive loss of blood from the body.

• a) Neutrophils

• b) Thrombocytes

• c) Erythrocytes

• d) Leucocytes

The process between a blood sample and the antiserum that causes the blood to clumping is called

• non-gluten

• coagulation

• agglutination

• clotting