Immune System Antigen Presentation Concepts

The video tutorial covers the processing and presentation of antigens by MHC Class I and II molecules, including the mechanisms of cross-presentation and viral evasion. It provides a detailed explanation of the molecular structures and functions involved in the immune response, highlighting the roles of different cells and proteins in antigen processing. The tutorial also discusses the significance of these processes in the context of immunology and potential viral strategies to evade immune detection.

What is the primary function of Class 1 molecules?

• To produce antibodies

• To present antigens to CD8+ T cells

• To activate B cells

• To present antigens to CD4+ T cells

Which molecule is always associated with Class 1 molecules?

• Beta 2 microglobulin

• Gamma globulin

• Alpha 1

• Delta chain

What is the role of the proteasome in Class 1 molecule processing?

• To bind to antigens

• To synthesize new proteins

• To degrade proteins into peptides

• To transport peptides to the cell surface

What is the function of the TAP transporter in Class 1 processing?

• To degrade proteins

• To transport peptides into the endoplasmic reticulum

• To synthesize proteins

• To present antigens on the cell surface

What prevents Class 2 molecules from binding peptides in the endoplasmic reticulum?

• The presence of calnexin

• The absence of proteasomes

• The presence of the invariant chain

• The presence of TAP

Which cells are considered professional antigen-presenting cells?

• Neutrophils, Eosinophils, Basophils

• Fibroblasts, Endothelial cells, Epithelial cells

• Macrophages, Dendritic cells, B cells

• T cells, B cells, NK cells

What is cross-presentation?

• The presentation of antigens by B cells

• The presentation of exogenous antigens by Class 1 molecules

• The presentation of antigens by neutrophils

• The presentation of endogenous antigens by Class 2 molecules

Which cells are capable of cross-presentation?

• Dendritic cells

• B cells

• Macrophages

• T cells

How do some viruses evade the immune system?

• By increasing the expression of Class 1 molecules

• By blocking the TAP transporter

• By enhancing proteasome activity

• By promoting antigen presentation

Which molecule is involved in the presentation of glycolipids?

• TAP transporter

• Class 1 molecules

• Class 2 molecules

• CD1 molecules