Med chem: PPIs (through slide34)

PPIs are widely used as treatment of ...

• duodenal ulcers

• gastric ulcers

• GERD

• hypersecretory conditions (Zollinger-Elllison syndrome)

PPIs work at the ____ step of acid secretion.

• first step

• final step

Inhibit the H/K ATPase enzyme irrespective of the receptor stimulation process.

• H2RA

• PPI

• antacids

Where do PPIs work?

• K/H antiporters

• M3 receptors

• H2 receptor

Answer explanation

PPIs are reversible/irreversible inhibitors?

• reversible

• irreversible

Select all that is true of PPI dosage forms

• acid sensitive

• capsules allow more time to degrade

• capsules protect from early activation

Which form of PPI is the active form?

• 
• 

The H/K ATPase is a large protein made of 2 subunits:

• catalytic alpha

• glycosylated regulatory Beta

Which subunit of the K/H ATPase protein is the catalytic portion?

• alpha

• beta

Which subunit of the K/H ATPase is glycosylated and regulatory?

• alpha

• beta