MICR Midterm

Which of the following are possible light chain isotypes?

• λ

• Κ

• β

• μ

• γ

Answer explanation

Light chains can either be of isotype kappa (κ) or isotype lambda (λ) - never both!

This is randomized.

The hinge region lies between the...

• 2 constant domains of the heavy chains

• Constant domains of the heavy chains & light chains

• Variable domains of the heavy chains & light chains

Answer explanation

Organize these lymphoid organs / tissues into the right category

Groups:

(a) Central/primary

,

(b) Peripheral/secondary

• Spleen

• Lymph nodes

• Bone marrow

• Thymus

Mucosal surfaces have specialized immune structures in the gut mucosa called _______ that contain B & T cells. This is because their lining is thin so they have their own special lymph node system.

Answer explanation

The humoral component of innate immunity is ______

Answer explanation

An ______ (aka antigenic determinants) is the region or antigen site that is recognized by the immune system (e.g., binds to lymphocyte receptors). These bind to specific Igs (immunoglobulins) or TCRs

Answer explanation

Lymphocyte receptors include antibodies or T cell receptors

Antibodies/BCRs are also known as ______, produced by B cells in a vast range of antigen specificities. However, each B cell produces ______ of a single-specificity

Answer explanation

Each B cell recognizes ONE type of pathogen only and makes ONE type of antibody only.

Which of the following is not a heavy chain isotype?

• IgD (δ)

• IgA (α)

• IgB (β)

• IgM (μ)

• IgG (γ)

Answer explanation

Replacing this, the correct lineup would include IgE (ε, epsilon)

In contrast, light chains can either be of isotype kappa (κ) or isotype lambda (λ) - never both!

This is randomized.

Which of the following is the first class of immunoglobulin co-expressed with IgM?

• IgD (δ)

• IgA (α)

• IgE (ε)

• IgG (γ)

Within an immunoglobulin exists _ heavy chains and _ light chains. Heavy chains are connected via _ disulfide bond(s). Each heavy chain is connected to a light chain via _ disulfide bond(s), totalling _ disulfide bonds across an immunoglobulin (antibody).

Type numbers as A, B, C, D, E

Answer explanation