Genetics of Alzheimer's Disease Quiz

What is the heritability percentage of Alzheimer's Disease (AD)?

• 50%

• 70%

• 90%

• 30%

What is the primary role of tau protein in neurons?

• Stabilizing microtubules

• Breaking down amyloid plaques

• Generating electrical impulses

• Producing neurotransmitters

Which hypothesis was introduced in the 1980s regarding AD?

• Genetic drift hypothesis

• Amyloid cascade hypothesis

• Natural selection hypothesis

• Chromosomal theory

What is the length range of the β-amyloid peptide?

• 20-25 amino acids

• 36-43 amino acids

• 50-60 amino acids

• 10-15 amino acids

How does hyperphosphorylation of tau protein affect its localisation?

• Enhances its ability to stabilize microtubules

• Leads to the formation of neurofibrillary tangles

• Increases its solubility in the cytoplasm

• Prevents its interaction with amyloid-beta

What is the role of amyloid in the necroptosis study's findings?

• It prevents tau phosphorylation

• It drives tau phosphorylation

• It has no effect on tau

• It reduces neuronal degeneration

What is a weakness of the amyloid cascade hypothesis regarding Aβ & Aβ plaques in the brain?

• Aβ & Aβ plaques correlate with the severity of AD cognitive impairment.

• Aβ & Aβ plaques do not correlate with the severity of AD cognitive impairment.

• Aβ & Aβ plaques are the sole cause of AD progression.

• Aβ & Aβ plaques always indicate cognitive decline.

What was the outcome for mouse neurons in the necroptosis study?

• 50% degeneration

• No degeneration

• Complete degeneration

• Partial degeneration

What process leads to the formation of β-amyloid?

• Glycosylation of APP

• Proteolytic cleavage of APP

• Phosphorylation of APP

• Methylation of APP

Which of the following is a consequence of tau aggregation in Alzheimer's Disease?

• Improved synaptic function

• Neuronal cell death

• Increased neurotransmitter release

• Enhanced memory retention