Reading Signal Transduction Pathways

Examine the Signal Transduction pathway below and put the events in the correct order.

• Ligand binds to the receptor

• Response occurs in the cell.

• Relay Protein 2 is activated

• Relay Protein 1 is activated

Examine the Signal Transduction pathway and put the events in the correct order.

• cAMP activates an enzyme called protein kinase A (PKA)

• adenylyl cyclase converts ATP into cAMP, removing two phosphates and linking the remaining phosphate to the sugar in a ring shape.

• Response occurs in the cell.

• Ligand binds to the receptor

Examine the Signal Transduction pathway and put the events in the correct order.

• an enzyme called phospholipase C cleaves (chops) PIP2 into two fragments, DAG and IP3

• Response occurs in the cell.

• DAG stays in the plasma membrane and activates a target called protein kinase C (PKC)

• Ligand binds to the receptor

• Phosphorylation occurs

Examine the Signal Transduction pathway and put the events in the correct order.

• IP3 - diffuses into the cytoplasm and can bind to ligand-gated calcium channels in the endoplasmic reticulum

• Ligand binds to the receptor

• an enzyme called phospholipase C cleaves (chops) PIP2 into two fragments, DAG and IP3

• Response occurs in the cell.

• Ca2+ is released and binds to proteins

Tags

NGSS.HS-PS1-2

Examine the Signal Transduction pathway and put the events in the correct order.

• • Active Raf phosphorylates and activates MEK, which phosphorylates and activates the ERKs.

• activated receptors trigger a series of events that activate the kinase Raf.

• Ligand (growth factor) binds to the EGF receptor

• Response occurs in the cell.

• ERKs phosphorylate and activate a variety of target molecules.