Theme Seminar: Genes and Mutation

Which of the following statements is true about nucleic acid?

• They contain peptide bonds.

• They have directional polarities arising from the sugars they contain.

• They contain phosphodiester bonds that join the bases

• Two nucleic acids are joined by a glycosidic linkage.

• They have a positively charged phosphate backbone.

Which of the following statements is true about mutations?

• They can produce new alleles of existing genes.

   

• They can be inherited if they are in somatic cells.

• They are never as simple as an error in a single   codon in a DNA molecule.

Most known human mutations:

• are caused by radiation

• appear to be spontaneous

• are due to viruses

In which of the following cells/tissue would you expect β-globin gene to be unmethylated?

• Erythroid cells

•   Kidney

• Liver

• Skin

• White blood cells

Modification of histone proteins by acetylation will

• Add methyl groups to the regulatory region of target genes

• Increase condensation of chromatin

• Increase the affinity of histones for DNA

• Increase the transcription of target genes

• Inhibit RNA polymerase activity

A silent mutation is highly unlikely to affect protein because:

• The dominant allele can compensate for the silent mutation

• Multiple codons can code for the same amino acid

• The silent mutation does not cause a frameshift

Which of the following represents a transition?

• T → A

• G →A

• A →T

• G →C

IDENTIFY THE TYPE OF MUTATION

ON (I) DNA and (II) PROTEIN LEVEL

IDENTIFY THE TYPE OF MUTATION

ON (I) DNA and (II) PROTEIN LEVEL

IDENTIFY THE TYPE OF MUTATION

ON (I) DNA and (II) PROTEIN LEVEL