PBS Sickle Cell

Sickle Cell Anemia is caused by a bad gene. What are genes?

• Like your fingerprints

• Blood passed down from parents to children

• Instructions made of DNA

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What happens to the blood cells of patients with Sickle Cell Anemia?

• Their blood is too thick. The heart works too hard.

• Their blood cells are sickle shaped. It makes clumps.

• Their blood cells are light red. They carry less oxygen.

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Gene therapy means fixing the DNA. How does this fix the sickle cells?

• DNA tells the cells what shape to be. If the DNA is right, the red blood cells can be round.

• DNA says how to make each protein. If the DNA is right, it makes healthy hemoglobin proteins in the red blood cells.

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What could probably happen if there's a MUTATION in the DNA?

• The person will probably have superpowers

• The ribosomes can fix it

• It makes a bad protein, like in Sickle Cell Anemia

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Why would blocking blood flow cause organ damage?

• The blood can't carry oxygen to the organs

• The blood can't carry water to the organs

• The blood flow stopped

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What is the primary cause of sickle cell disease?

• A genetic mutation in the hemoglobin gene

• A viral infection

• A deficiency in iron

• An autoimmune disorder

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Which of the following is a characteristic shape of red blood cells in sickle cell disease?

• Spherical

• Sickle-shaped

• Oval

• Irregular

What is the main function of hemoglobin in red blood cells?

• Transporting oxygen

• Fighting infections

• Clotting blood

• Carrying nutrients

Which type of genetic inheritance pattern does sickle cell disease follow?

• Autosomal dominant

• Autosomal recessive

• X-linked dominant

• X-linked recessive

What is the primary symptom of sickle cell anemia?

• Chronic fatigue

• Joint pain

• Frequent infections

• All of the above