Quiz on Erythropoiesis and Erythrocyte Maturation

What is the major cytokine involved in erythropoiesis?

• Interleukin-6

• Erythropoietin

• Granulocyte-macrophage colony-stimulating factor

• Thrombopoietin

Which of the following is a precursor to erythrocytes?

• CFU-GEMM

• Megakaryocyte

• Lymphocyte

• Basophil

How long does it take for a pronormoblast to mature into a red blood cell?

• 3 weeks

• 6-7 days

• 18-21 days

• 24-48 hours

What is the N:C ratio of a pronormoblast?

• 6:1

• 8:1

• 4:1

• 1:2

Which stage of erythrocyte maturation is characterized by the first visible hemoglobin?

• Pronormoblast

• Basophilic normoblast

• Orthochromic normoblast

• Polychromatic normoblast

What happens to the nucleus during the orthochromic normoblast stage?

• It becomes more prominent

• It is ejected from the cell

• It enlarges

• It divides

What is the primary function of erythropoietin (EPO)?

• Stimulate platelet production

• Increase white blood cell count

• Regulate iron metabolism

• Promote red blood cell production

Which of the following describes the appearance of reticulocytes?

• Small and colorless

• Anucleated with bluish tinge

• Large and pink

• Nucleated and large

What is the role of hepcidin in erythropoiesis?

• Inhibits iron release

• Stimulates EPO production

• Promotes iron absorption

• Enhances hemoglobin synthesis

What is the lifespan of a mature erythrocyte?

• 120 days

• 90 days

• 30 days

• 60 days