biochemistry

The correct sequence of the stages of mitosis is represented by which of the following?

• Prophase, prometaphase, metaphase, telophase, anaphase

• Prophase, prometaphase, metaphase, anaphase, telophase

• Telophase, prophase, prometaphase, metaphase, anaphase

• Anaphase, prometaphase, metaphase, anaphase, prophase

Which of the following functions is associated with eukaryotic DNA polymerases during DNA replication?

• Continuous 5' to 3' DNA synthesis on the lagging strand

• Energy dependent formation of the replication fork

• Proof reading newly synthesised DNA

• Removal of primers using 5' to 3' exonuclease activity

Which of the following characterizes the telophase stage of mitosis?

• Nuclear envelope disassembles

• Sister chromatids migrate towards poles

• Disassembly of kinetochore microtubules

• Cytoplasmic division occurs

Defective mismatch repair can result in the development of

• Hereditary non polyposis colorectal cancer

• Sickle cell anemia

• Hereditary hemochromatosis

• Xeropthalmia pigmentosum

In the cell cycle, the following are correct EXCEPT

• G1 phase is metabolically inactive

• DNA replication takes place in S phase

• In G2 phase the enzymes and proteins are synthesised for cell division.

• The division of the nucleus of the cell into two new nuclei in M phase.

Which reaction in DNA replication is catalyzed by DNA ligase?

• Addition of new nucleotides to the lagging strand

• Addition of new nucleotides to the leading strand

• Base pairing of the template and the newly formed DNA strand.

• Formation of a phosphodiester bond between the 3'-OH of one Okazaki fragment and 5'-phosphate of the next the lagging strand

Which one of the following enzymes catalyses the synthesis of mRNAs in eukaryotes

• RNA polymerase I

• RNA polymerase II

• RNA polymerase III

• DNA polymerase

In which of the following parts of a gene, TATA box sequence is found?

• Promoter

• Intron

• Exon

• Terminator

Which of the following dimer formation commonly occurs?

• Thymidine dimer

• Adenine dimer

• Cytidine dimer

• Uracil dimer

Sickle cell anemia is a classic example for

• Point mutation

• Silent mutation

• Frame shift mutation

• Nonsense mutation