Glycolysis Quiz

Which of the following is the primary purpose of glycolysis in most cells?

• Aerobic oxidation of glucose to CO2 and H2O

• Anaerobic oxidation of glucose to pyruvate/lactate

• Synthesis of glycogen from glucose

• Breakdown of fatty acids

• Production of amino acids

What is the normal range of glucose concentration in peripheral blood?

• 2-4 mM (36-72 mg/dL)

• 4-6 mM (70-110 mg/dL)

• 8-10 mM (144-180 mg/dL)

• 10-12 mM (180-216 mg/dL)

• 12-14 mM (216-252 mg/dL)

Glucose transport into cells via facilitated diffusion is characterized by

• Energy-dependent transport against a concentration gradient.

• Movement of glucose down its concentration gradient with the help of a specific protein transporter.

• Direct phosphorylation of glucose during transport.

• Transport of glucose independent of any protein transporters.

• Coupled transport of glucose with sodium ions.

Which of the following transporters is insulin-sensitive and found in skeletal muscle, heart, and adipose cells?

• GLUT1

• GLUT2

• GLUT3

• GLUT4

• SGLT1

Fill in the blanks: GLUT 1 and GLUT 3 mediate basal glucose uptake in most tissues. Their high affinities for glucose ensure glucose entry even during periods of relative ____________. At normal glucose concentration, GLUT 1 and GLUT 3 are at ________.

• hyperglycemia, Km

• hypoglycemia, Km

• hyperglycemia, Vmax

• hypoglycemia, Vmax

Fill in the blanks: GLUT 2, a low-affinity transporter, is in hepatocytes. After a meal, portal blood from the intestine is rich in glucose. GLUT 2 captures the excess glucose primarily for ________. In the β-islet cells of the pancreas. GLUT-2, along with glucokinase, serves as the glucose sensor for ________ release.

• energy, glucagon

• glycolysis, amylin

• storage, insulin

• export, somatostatin

• signaling, secretin

Under aerobic conditions, what is the fate of pyruvate produced during glycolysis?

• Conversion to lactate

• Conversion to ethanol

• Complete oxidative degradation to CO2 and H2O via the citric acid cycle and electron transport chain

• Conversion to glycogen

• Excretion from the cell

Red blood cells rely entirely on which pathway for energy?

• Citric acid cycle

• Oxidative phosphorylation

• Glycolysis

• Fatty acid oxidation

• Gluconeogenesis

How many molecules of ATP are generated during glycolysis when one molecule of glucose is converted to two molecules of pyruvate?

• 1

• 2

• 3

• 4

• 36

Which of the following enzymes is NOT directly involved in the regulation of glycolysis?

• Hexokinase

• Glucokinase

• Phosphofructokinase (PFK-1)

• Pyruvate kinase

• Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)