Chronic Myelogenous Leukemia Overview

What is Chronic myelogenous leukemia (CML)?

• A cancer of the white blood cells

• A type of skin cancer

• A heart disease

• A respiratory illness

What causes Chronic myeloid leukemia?

• Genetic material rearrangement

• Viral infection

• Environmental factors

• Dietary habits

What is the duration of the chronic phase in CML?

• 3-5 years

• 1-2 years

• 5-10 years

• Less than a year

What percentage of patients present in chronic phase at diagnosis?

• 85%

• 50%

• 30%

• 100%

What is the final phase in the evolution of CML?

• Blast crisis

• Chronic phase

• Accelerated phase

• Remission

What is the typical lab finding in the bone marrow for CML?

• Hypercellular with increased M:E ratio

• Hypocellular

• Normal cellularity

• Necrosis

What is the LAP score in CML?

• Decreased

• Increased

• Normal

• Variable

What is the chromosomal mutation associated with CML?

• t(9;22)

• t(8;21)

• t(15;17)

• t(11;14)

What are the immunological markers for CML?

• CD13, CD14, CD15, CD33

• CD4, CD8, CD19

• CD34, CD45

• CD56, CD57

What is the typical blood film examination finding in CML?

• Normocytic and normochromic anemia

• Microcytic anemia

• Macrocytic anemia

• Hemolytic anemia