Eicosanoids and Fatty Acids Quiz

Eicosanoids are derived from which type of fatty acid?

• Saturated fatty acids

• Trans fatty acids

• 20-carbon polyunsaturated fatty acids

• Medium-chain fatty acids

Which of the following is not a class of eicosanoids?

• Prostaglandins

• Leukotrienes

• Thromboxanes

• Sphingolipids

What enzyme releases arachidonic acid from membrane phospholipids?

• Lipase D

• Phospholipase A2

• Cyclooxygenase

• Protein kinase C

Which omega fatty acid is the main precursor of pro-inflammatory eicosanoids?

• Omega-3

• Omega-6

• Omega-9

• Omega-7

The cyclooxygenase pathway converts arachidonic acid into:

• Leukotrienes

• Prostaglandins and thromboxanes

• Histamine

• Cytokines

Which pathway is responsible for the synthesis of leukotrienes?

• Glycolytic pathway

• Lipoxygenase pathway

• TCA cycle

• Pentose phosphate pathway

Which of the following eicosanoids promotes platelet aggregation?

• PGI2

• PGE2

• TXA2

• LTB4

Leukotrienes are how many times more potent than histamine in allergic responses?

• 10x

• 50x

• 100x

• 200x

Aspirin prevents platelet aggregation by irreversibly inhibiting:

• COX-2 in platelets

• COX-1 in platelets

• Lipoxygenase in leukocytes

• DAG lipase in liver

Why can endothelial cells recover COX enzyme activity after aspirin intake?

• They are resistant to aspirin

• They contain lipoxygenase

• They have a nucleus

• They don’t express COX enzymes