HIV Pathology Part 2

What is the primary mechanism of action of NNRTIs?

• Mimic nucleosides to terminate DNA chains

• Inhibit protease cleavage of viral proteins

• Bind directly to reverse transcriptase at a non-active site

• Block viral entry into host cells

Which of the following NNRTIs is known for causing vivid dreams and CNS effects?

• nevirapine

• efavirenz

• rilpivirine

• doravirine

Which of the following NNRTIs is considered a second-generation agent with improved resistance profile?

• nevirapine

• efavirenz

• rilpivirine

• zidovudine

What is a major disadvantage of NNRTIs compared to other antiretroviral classes?

• poor oral bioavailability

• high cost

• low genetic barrier to resistence

• need for boosting agents

What is a key difference between NNRTIs and NRTIs?

• NNRTIs require phosphorylation for activation

• NNRTIs are nucleoside analogs

• NNRTIs bind directly to reverse transcriptase without mimicking nucleosides

• NNRTIs inhibit integrase

Which of the following is a correct mnemonic to remember common NNRTIs?

• LATE

• REDEN

• NAVIR

• GRAVIR

Which NNRTI is known for having the fewest CNS side effects and a favorable lipid profile?

• efavirenz

• doravirine

• nevirapine

• zidovudine

What is the role of NNRTIs in antiretroviral therapy (ART)?

• used only for post-exposure prophylaxis

• used as monotherapy

• used in combination regimens to inhibit reverse transcriptase

• used to inhibit viral entry

Which of the following NNRTIs is most likely to be used in patients with prior NNRTI resistance?

• efavirenz

• nevirapine

• etravirine

• zidovudine

Which NNRTI is most associated with hepatotoxicity and rash, especially in women with higher CD4 counts?

• efavirenz

• nevirapine

• doravirine

• etravirine