Cholinergic Pharmacology Quiz

Which of the following cranical nerve does not contain parasympathetic motor fibers?

• Oculomotor nerve

• Abducent nerve

• Glossopharyngeal nerve

• Vagus nerve

Mechanism of action of pralidoxime is:

• Stimulation of ACh receptors

• Inhibition of breakdown of Ach

• Blockade of ACh receptors

• Reactivation of AChE enzyme

Diagnosis of myasthenia gravis is done by using:

• Edrophonium

• Neostigmine

• Succinylcholine

• Atropine

All of the following effects are seen with cholinergic muscarinic receptor stimulation except:

• Sweating

• Rise in blood pressure

• Bradycardia

• Urination

Which drug is immediately administered to counteract muscarinic symptoms in acute organophosphate poisoning?

• Atropine

• Pralidoxime

• Neostigmine

• d- Tubocurarine

Organophosphates bind to:

• Anionic site of AChEs

• Esteratic site of AChEs

• Ach

• Acetyl CoA

Atropine is useful in organophosphate poisoning because it:

• Reactivates acetylcholinesterase

• Competes with acetylcholine release

• Binds with both nicotinic and muscarinic acetylcholine receptors

• Is a competitive antagonist of acetylcholine

Neostigmine used in treatment of myasthenia gravis acts by:

• Increasing the number of receptors for acetylcholine

• Increasing synthesis of acetylcholine

• Decreasing breakdown of acetylcholine

• Increasing actylcholine degradation

Acetylcholine is not used commercially because:

• Long duration of action

• Costly

• Rapidly destroyed in the body

• Crosses blood brain barrier

Which of the following cholinergic agonists is used to stimulate bladder contraction?

• Bethanechol

• Scopolamine

• Glycopyrolate

• Atyropine