Coticosteroid Quiz

A 45-year-old male is prescribed prednisone for an autoimmune condition. He asks how it works.
Which of the following best describes the mechanism of action of corticosteroids like prednisone?

• Inhibits bacterial protein synthesis

• Blocks histamine H1 receptors

• Suppresses inflammation by inhibiting phospholipase A2

• Stimulates T-cell proliferation

A patient with rheumatoid arthritis reports reduced joint pain after taking corticosteroids.
The anti-inflammatory effect of corticosteroids is primarily due to:

• Inhibition of leukocyte production
  

• Increased histamine release

• Stimulation of pro-inflammatory cytokines

• Inhibition of prostaglandin release

What is the main mechanism by which steroid hormones exert their effects?

• Activation of G-protein coupled receptors

• Phosphorylation of membrane proteins

• Direct modulation of gene transcription

• Inhibition of ion channels

Corticosteroids suppress inflammation by inhibiting which one of the following enzyme

• COX-2 enzyme

• Phospholipase 2 enzyme

• Monoamine oxidase enzyme

• Acetylcholinesterase enzyme

Which one of the following is the location of steroid hormone receptors within the cell?

• Nucleus/Cytoplasm

• Cell membrane
  

• Mitochondria

• Endoplasmic Reticulum

A postmenopausal woman is on long-term corticosteroids for lupus.
Which long-term adverse effect should be closely monitored?

• Renal failure

• Osteoporosis

• Gout

• Blindness

A diabetic patient started on corticosteroids notices an increase in blood sugar levels.
Corticosteroids can increase blood glucose by:

• Enhancing insulin secretion
  

• Blocking glucose absorption

• Stimulating gluconeogenesis

• Inhibiting pancreatic beta cells

A known adverse effect of corticosteroids on the gastrointestinal tract is:

• Pancreatitis

• Esophageal varices

• Peptic ulcer

• Constipation

Which one of the following is exogenous steroid ?

• Cortisol

• Aldosterone

• Hydrocortisone

• Androgens