Dissolution quiz -Practice school

Which among the following is the type - 3 dissolution setup, as recommended by US-FDA

• Basket type

• Reciprocating cylinder

• Paddle type

• Flow through cell

Drug dissolution is a _____ process involving heterogeneous reactions at the solid–liquid interphase.

• None of above

• linear steps

• single step

• Multi-step

Which parameter is primarily measured in a dissolution test?

• Integrity of tablet

• amount of drug released over time

• Drug content/purity

• Release of colour from tablet

Which wavelength is typically used to analyze paracetamol during UV spectrophotometric dissolution assay?

• 234

• 243

• 257

• 220

During the analysis of content from dissolution of paracetamol tablets, if absorbance keeps increasing beyond the calibration range, what should be done?

• Continue measurement

• Increase wavelength

• Dilute the sample appropriately

• Change the buffer

Which parameter remains constant in a dissolution test unless intentionally varied?

• Time of sampling

• Type of medium

• Speed of paddle

• Surface area of drug

The calibration curve in dissolution helps to:

• Set zero in the spectrophotometer

• Compare unknown absorbance to known concentrations

• Measure the intensity of peaking of drug sample

• Validate the drug profile

Why is degassing of dissolution medium done?

• To sterilize it

• To improve drug solubility

• To avoid bubble formation on dosage form

• To reduce pH

The term “Q value” in dissolution refers to:

• Quantity of drug in tablet

• Quality of UV spectrum absorbance predicted

• Specified amount (%) of drug release required

• Rate of drug absorption

what is the maximum volume of the dissolution media holding bowl in the apparatus (in ml)

• 1000

• 1100

• 500

• 900