Workshop 07/30/2025

ADP assembly happens on the positive end with the higher critical concentration.

• True

• False

Tags

NGSS.HS-LS1-7

NGSS.HS-LS2-3

What happens if beta-thymosin4 is mutated?

• G-actin monomers would not be stored

• Filaments would becoem more branched

• Profilin levels would increase

• Actin polymerization would stop

Tags

NGSS.HS-LS3-2

How would profilin’s absence in a cell affect ATP G-actin polymerization?

• Profilin would increase disassembly

• Actin polymerization would only occur at the negative end

• Actin polymerization would happen at the negative end at a higher rate

• Actin polymerization would be blocked

If cofilin activity is lost, what would happen to actin polymerization?

• Actin filaments would be highly branched

• ATP-actin would accumulate

• Greater negative ends would be available

• Irregular filament length

A cell has a calcium deficiency, which protein would most likely be affected?

• Tropomodulin

• CapZ

• Gelsolin

• Profilin

How would gelsolin inactivity change filament length? 

• Increased filament severing

• Filament length would be longer

• Stabilized filaments

• Increased ATP hydrolysis

What happens if there is a mutation in CapZ?

• Profilin becomes useless

• Filament length would be longer on the + end

• Filament length would be longer on the - end

• Filament length would be longer on the + and - end

What protein concentration would have to be increased to stabilize actin filament?

• Tropomodulin

• Gelsolin

• Cofilin

• Beta Thymosin 4

What happens if formin is hyperactivated in all cells?

• Excess branched networks

• Unwanted long filaments would form 

• Arp2/3 would be down regulated

• Actin polymerization would stop

A pathogen uses Arp2/3 pathway, how would Arp2/3 inhibition affect the host cell?

• Leading membrane would be pushed in a moving cell

• Pathogen movement within a cell would increase

• Endocytosis would be blocked within the cell 

• Branched networks would increase