(PR202) ImmunoQuiz - L6. HIR

Which site is the primary location for B cell maturation after birth?

• Thymus

• Fetal liver

• Bone marrow

• Lymph nodes

Correctly label the following region of an immunoglobulin.

a

b

c

f

g

Fc region

Fc receptor

Hinge

Constant region

Light chain

Antigen-binding site

Heavy chain

Fab

During B cell maturation, which immunoglobulin is first expressed on the cell surface?

• IgG

• IgM

• IgD

• IgA

• IgE

The component that delivers activation signals in the B cell receptor (BCR) complex is ​ ​ (a)  

• Igα and Igβ
• IgM
• IgD
• Fab region

Thymus-independent type 1 (TI-1) antigens can activate B cells by​ ​ (a)  

• Binding to Toll-like receptors (TLRs)
• Binding to Fc receptors
• Presenting via MHC class II
• Binding to BCR only

The first antibody produced during a primary immune response is...

• IgA

• IgM

• IgG

• IgD

Complementarity-determining regions (CDRs) are found in​ ​ (a)  

• variable regions
• hinge regions
• Fc regions
• constant regions

Which immunoglobulin class is most abundant in mucosal secretions?

• IgE

• IgM

• IgA

• IgG

Receptor editing in B cells primarily changes the​ ​ ​ (a)  

• light chain variable region
• light chain constant region
• heavy chain constant region
• heavy chain variable region

Which antibody class is the most potent activator of the classical complement pathway?

• IgA2

• IgG4

• IgM

• IgE