final Basic pharmacology exam

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the time needed by the body to reduce the plasma concentration of any drug by 50%

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constant (steady) plasma concentration should be reached and maintained

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drugs that block the receptors thus preventing the action of the agonist,

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competitior between the agonist and antagonist on the same receptor, and excess agonist can displace the antagonist.

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antagonist cannot be displaced by excess agonist. They cause "non- parallel shift to the right with reduced efficacy" of the agonist log dose/ response curve,

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the effect of the antagonist is of short duration because it is rapidly metabolized

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_the effect of the antagonis is prolonged because it binds to the receptor by a 'covalent bond", and its effect is terminated by synthesis of new receptors

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the maximum response obtained by the drug. Drugs with high efficacy are known as "high ceiling" e.g. loop diuretics.

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This is diffusion and transport of the drug molecules and accompanyin water across arrow junctions between cells or trans-endothelial channels.

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the dose that achieves 50% of the maximal response (the lower the ED s0 the more potent the drug).