Immunity and Vaccine Development for Neisseria meningitidis

What is the case-fatality rate of untreated Neisseria meningitidis cases?

• Near 100%

• 5% to 15%

• 50% to 70%

• 10%

Which serogroups of Neisseria meningitidis are most common in developed countries?

• B, C, Y, W135

• A, B, C, Y

• A, C, Y, W135

• B, C, W135, X

Why is the polysaccharide capsule of serogroup B poorly immunogenic?

• Similarity to human brain and fetal antigens

• Lack of immune memory

• High mutation rate

• Low antibody affinity

What is the efficacy range of outer membrane vesicle (OMV) vaccines in trials?

• 51% to 80%

• 30% to 50%

• 70% to 90%

• 40% to 60%

What cytokine response is skewed in young children after meningococcal infection?

• TH1 response

• TH2 response

• TH17 response

• Treg response