40 Multiple Choice Questions on CBC, Anemia, and Morphology

• Poikilocytosis

• Hypochromasia

• Anisocytosis

• Polychromasia

• One-half

• One-third

• Two-thirds

• The entire cell

• Codocyte (Target Cell)

• Schistocyte

• Spherocyte

• Macroovalocyte

The alignment of RBCs into stacks resembling a pile of coins is called Rouleaux. Pathologically, this finding is associated with an increase in plasma proteins, which is frequently seen in which malignant disorder?

• Iron Deficiency Anemia

• Hereditary Spherocytosis

• Multiple Myeloma

• Acute Alcohol Intoxication

When a blood sample collected in EDTA demonstrates RBCs forming irregular clusters, and the automated cell counter shows a falsely increased MCH and decreased RBC count, the issue is likely Cold Agglutinin. What is the common method to eliminate this interference and obtain accurate results?

• Recalculate the indices based on the Rule of Three

• Collect the sample in a blue top (Sodium Citrate) tube

• Examine only the feathered edge of the smear

In a case of Platelet Satellitism, platelets adhere to neutrophils, leading to a falsely decreased platelet count. How can this collection interference be eliminated?

• Preparing the smear within 3 hours of collection

• Using sodium citrate (blue top) as the anticoagulant

• Performing a WBC differential count under oil immersion

• Confirming the result with a delta check

A normal discocyte typically shows a central area of pallor that occupies approximately one-third of the cell's diameter. What type of cell is formed when the cell has an increased surface-to-volume ratio, causing it to look like a bull's eye with central condensation of hemoglobin?

• Stomatocyte

• Echinocyte

• Codocyte (Target Cell)

• Drepanocyte (Sickle Cell)

Poikilocytosis is the term used to describe nonspecific variation in the shape of RBCs. Which specific shape abnormality is produced when the RBC membrane is impaled on a fibrin strand, resulting in a blister cell that ultimately leaves a notch with two spicules?

• A. Acanthocyte

• B. Keratocyte (Helmet Cell)

• C. Elliptocyte

• D. Dacryocyte